p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often …

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the …

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing …

Dec 19, 2025 · The TP53 gene is frequently mutated in many cancers. Learn about the function of this gene, how it plays a role in cancer, and approaches to treatment.

Apr 6, 2026 · The p53 protein, encoded by the TP53 gene, is expressed in almost all human tissues and plays a pivotal role in cancer suppression as a tumor suppressor. The transcription factor activity of …

Jan 15, 2026 · p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (e.g. hypoxia, DNA and spindle damage).

The p53 gene, officially known as TP53, is a critical tumor suppressor in human biology. This gene encodes the p53 protein, which acts as the cell’s primary safeguard against the uncontrolled …

May 9, 2024 · Numerous efforts have been dedicated to understanding p53. In return for this, we now have a better picture of this gene (Figure 1). However, there are still certain aspects of p53 that …

p53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression. It is very important for cells in multicellular …

Jun 10, 2024 · Here, we review the complexity of different layers of p53 regulation, and the recent advance of the p53 pathway in metabolism, ferroptosis, immunity, and others that contribute to tumor …