Two U.S. Navy destroyers crossed the Strait of Hormuz as U.S. and Iranian negotiators meet for face-to-face negotiations amid a fragile truce.

Sources tell CNN that marathon US-Iran negotiations in Pakistan have been largely positive but that the Strait of Hormuz remains a key sticking point. Follow for live updates.

Iranian supreme leader Mojtaba Khamenei is severely disfigured after U.S.-Israel airstrikes on Tehran killed his father, according to a Reuters report citing anonymous sources.

The accounts of the people close to Khamenei's inner circle provide the most detailed description of the leader's condition for weeks.

US intelligence indicates that China is preparing to deliver new air defense systems to Iran within the next few weeks, according to three people familiar with recent intelligence assessments.

The long-term fallout of the war in Iran is only beginning to take shape, but this much is clear: The conflict has left the Middle East unsettled, alliances strained and the world facing uncertain shifts in the balance of economic and military power.

Iran threatened to attack any US Navy ships that enter the Strait of Hormuz shortly after American vessels moved through the channel for the first time since the war broke out.

Iranian negotiators and US Vice President JD Vance have reached Pakistan for make-or-break peace talks. Trump issues a 24-hour ultimatum on the Strait of Hormuz while Israel continues airstrikes in Lebanon despite the ceasefire.