Immune system disorders in children can involve an underactive, overactive, or misdirected immune response. Main groups include immunodeficiencies, autoimmune diseases, atopic diseases, and ...

New research from large population studies provides invaluable evidence on genome screening of newborn babies to reduce risks from overdiagnosis. The authors conclude that further studies are needed ...

Researchers have identified the genetic basis behind certain severe immunodeficiencies in newborns, paving the way for potential screening and emerging therapies. The findings, published today (24 May ...

Treatment with Xolremdi also results in a 60% reduction in the annualized infection rate compared with placebo-treated patients. The company has set a wholesale acquisition cost for Xolremdi annually ...

Scientists have pinpointed genetic changes that can leave children born with little to no immune defence against infection. In a new study of 11 affected individuals, researchers from Newcastle ...

Inborn errors of immunity, historically termed primary immunodeficiency disorders, encompass a diverse group of heritable conditions that compromise innate and adaptive immune function. These ...

Genomic integrity in lymphocytes relies on precise repair of DNA double-strand breaks (DSBs) introduced during antigen-receptor gene assembly and by exogenous insults. The non-homologous end joining ...

Primary immunodeficiency can increase your risk of many other health issues, so managing it is key to staying healthy. See how well you’re doing, and get simple steps for improving your immunity. It's ...

Like their causative mutations, pathophysiology and natural history, the clinical presentation of inborn errors of immunity (IEI) varies widely. Nevertheless, some features, above all recurrent and/or ...

Use precise geolocation data. Actively scan device characteristics for identification. Store and/or access information on a device. Personalised advertising and content, advertising and content ...

Living with primary immunodeficiency (PI) means getting sick more often than others, taking a long time to recover from an illness, and experiencing recurring infections. The uncertainty and ...

Scientists have pinpointed genetic changes that can leave children born with little to no immune defense against infection. In a new study of 11 affected individuals, researchers from Newcastle ...