Yeast filamentous growth is a highly regulated cellular differentiation response, enabling cells to assume an elongated morphology when confronted with environmental stress or nutrient limitation.

Researchers have visualized at the molecular level how formins bind to the ends of actin filaments. This allowed them to uncover how formins mediate the addition of new actin molecules to a growing ...

Formins are made of two identical parts (red, orange) that encircle the actin (grey) filament in a ring-like conformation. “Our discovery allows us to interpret decades of biochemical studies on ...