Radiochemists can now expand their toolbox of molecular probes for positron emission tomography (PET), thanks to a new electrophilic fluorinating reagent. The palladium-based compound is made with 18 ...

Scientists generalize the synthesis of aminating agents to simplify the design and manufacture of drugs and other fine chemicals in which nitrogen atoms play key roles. Each of these agents contains ...

Recently discovered electrophilic probes open the door to activity-based protein profiling (ABPP) studies of a broader range of proteins. It can be extremely challenging to study enzymes. Without any ...

In 2014, the European Medicines Agency approved the drug Tecfidera for the treatment of relapsing multiple sclerosis, a neurodegenerative disease that affects millions of people worldwide. In multiple ...

Organic chemists love their functional groups and perhaps the most hotly pursued of these amours is the amine. Arylamines, for example, are often important components of pharmaceuticals or other ...